Total Body and Marrow Irradiation (TBI & TMLI)

What is Total Body and Marrow Irradiation (TBI & TMLI)?

Total Body Irradiation (TBI) and Total Marrow and Lymphoid Irradiation (TMLI) are specialized radiation therapies used as part of conditioning regimens before stem cell or bone marrow transplantation. These treatments help eliminate cancerous cells, suppress the immune system to prevent transplant rejection, and prepare the body to accept healthy donor stem cells.

How TBI & TMLI Works?

TBI: Delivers uniform radiation across the entire body to destroy residual cancer cells and immune cells that could interfere with transplantation.
TMLI: A more targeted approach that focuses radiation on the bone marrow and lymphoid tissues while sparing other organs, reducing treatment-related toxicity.

Advanced imaging and computer-guided planning ensure precise dose delivery, protecting vital organs such as the lungs, liver, kidneys, and gastrointestinal tract.

Advantages of TBI & TMLI

Effective Conditioning: Prepares the body for successful stem cell or bone marrow transplant.
Reduced Toxicity (TMLI): Targets only necessary tissues, minimizing side effects compared to traditional TBI.
Enhanced Treatment Outcomes: Improves engraftment rates and reduces the risk of relapse in high-risk hematologic malignancies.

Who Can Benefit from TBI & TMLI?

Patients undergoing allogeneic or autologous stem cell transplantation for:

- Leukemia
- Lymphoma
- Multiple myeloma
- Other hematologic malignancies

Treatment Process

Consultation: Hematology and radiation oncology teams evaluate the patient’s condition and transplant plan.
Imaging and Planning: High-precision CT and MRI scans map the target tissues while protecting vital organs.
Radiation Delivery: Using advanced linear accelerators, TBI or TMLI is administered over multiple sessions according to the transplant protocol.
Monitoring and Support: Patients are closely monitored for treatment tolerance and side effects as part of the transplant journey.

Safety and Technology

TBI and TMLI are delivered under strict AERB (Atomic Energy Regulatory Board) guidelines. At Mar Sleeva Medicity Palai, we use cutting-edge imaging and planning systems to optimize dose delivery, ensuring patient safety while maximizing treatment effectiveness.

Integration with Stem Cell & Bone Marrow Transplant Program

TBI and TMLI are integral to our Stem Cell & Bone Marrow Transplant Program, providing patients with a comprehensive, multidisciplinary approach. Our team of hematologists, radiation oncologists, and transplant specialists work together to ensure safe, precise, and effective conditioning therapy before transplantation.

Why Choose Mar Sleeva Medicity Palai?

Expert Hemato-Oncology and Radiation Oncology teams
State-of-the-art technology for TBI and TMLI
Personalized care plans tailored to transplant protocols
Continuous support throughout the transplant journey

Frequently asked Questions

The department manages the full spectrum of gastrointestinal, hepatic, pancreatic and biliary conditions. This includes acid reflux disease, peptic ulcers, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), irritable bowel syndrome, liver diseases, pancreatitis, gastrointestinal bleeding, gastrointestinal cancers and all conditions requiring diagnostic or therapeutic endoscopy.

Capsule endoscopy involves swallowing a small, vitamin sized capsule containing a tiny camera. As it passes through the digestive tract, it captures thousands of images of the small bowel, an area that is difficult to reach with conventional endoscopy. It is used to evaluate conditions such as obscure gastrointestinal bleeding, Crohn’s disease and small bowel tumours.

Most endoscopic procedures are performed under conscious sedation or short general anaesthesia, so patients typically experience minimal discomfort. The gastroenterology team at Mar Sleeva Medicity Palai ensures patient comfort and safety with ICU level monitoring during and after the procedure.

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